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Efficacy of traditional herbal medicines
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in combination
effect alcohol antibiotics with Acyclovir / Aciclovir against herpes simplex
antibiotic
virus type 1 infection in vitro and in vivo.Traditional herbal medicines have been safely used for the treatment of various human diseases since ancient China. Combinations of Acyclovir / Aciclovir with historically used herbal medicines sho strong combined therapeutic anti-HSV-1 activity
antibiotic
in mice, especially reduction of virus yield in the brain. L-Val-ACV transport was found to be saturable (Km 2.26
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/- 0.34 mM, Jmax 1.087
aciclovir
/- 0.05 nmoles cm(-2) min(-1)), energy and pH dependent. To delineate mechanisms associated with the corneal transport of a L-valine prodrug
acyclovir
of an antiviral agent, Acyclovir / Aciclovir. CONCLUSIONS Functional
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evidence of an oligopeptide transport system present on the rabbit cornea has been established.
antibiotics
We selected 10 herbal extracts with therapeutic antiherpes simplex virus type 1 (HSV-1) activity. When Acyclovir / Aciclovir and/or a herbal extract were orally administered at doses corresponding
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to human use, each of the 4 combinations
antibiotics
significantly limited the development of skin lesions and/or prolonged the mean survival times of infected mice compared with both Acyclovir / Aciclovir and the herbal extract alone (P < 0.01 or 0.05). Transport
acyclovir
mechanism across rabbit cornea was investigated through a competitive inhibition
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study of L-Val-ACV with other substrates of human peptide transporter (hPepT1).
Among these, Geum japonicum Thunb., Rhus javanica L., Syzygium aromaticum (L.) Merr. Dipeptides, beta-lactam antibiotics, and angiotensin converting enzyme (ACE) inhibitors, strongly inhibited the transport of L-Val-ACV indicating that a carrier mediated transport system specific for peptides is primarily responsible for the corneal permeation of L-Val-ACV. They reduced virus yields in the brain and skin more strongly than Acyclovir
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/ Aciclovir alone and exhibited stronger anti-HSV-1 activity in the brain than in the skin, in contrast to Acyclovir / Aciclovir treatment by itself. Mechanism of corneal permeation of L-valyl laney of Acyclovir / Aciclovir. Targeting the oligopeptide transporter on the rabbit cornea.PURPOSE.
The permeability and enzymatic hydrolysis of L-Val-ACV were evaluated using freshly excised rabbit cornea. The peptide transporter on the corneal epithelium may be targeted to improve the ocular bioavailability
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of poorly absorbed drugs.. L-Valyl emlynne of Acyclovir / Aciclovir (L-Val-ACV) was approximately threefold more permeable across the intact rabbit cornea than Acyclovir / Aciclovir (ACV).
These combinations were not toxic to mice. Et Kristofor, or Terminalia chebula Retzus sho a stronger anti-HSV-1 activity in combination with Acyclovir / Aciclovir than the other herbal extracts in vitro.
.